DocumentCode
601226
Title
Effects of reaction condition and feed composition on thermo-gelling behavior of PLGA-PEG-PLGA
Author
Hosayni, L. ; Ganji, Fatemeh ; Khodaverdi, E.
Author_Institution
Biomedical group, Faculty of Chemical Engineering, Tarbiat Modares University, Tehran, Iran
fYear
2012
fDate
20-21 Dec. 2012
Firstpage
118
Lastpage
120
Abstract
Intelligent thermosensitive formulations based on PLGA-PEG-PLGA triblock copolymer have great potential in biomedical applications, due to their good biocompatibility, biodegradability and injectability. The gelation behavior of the synthesized PLGA-PEG-PLGA triblocks was investigated in this study and the effect of PEG molecular weight and lactide to glycolide molar ratio, as well as the reaction time was investigated. Triblocks with PEG1000 have shown inappropriate gelation; while those with higher molecular weight formed gel at body temperature. The insulin release profiles showed an approximately linear release profile without a non-desirable burst effect More than 80% of the insulin was released during 4 weeks.
Keywords
Gelation behavior; Insulin; PLGA-PEGPLGA; Thermosensitive; Triblock copolymer;
fLanguage
English
Publisher
ieee
Conference_Titel
Biomedical Engineering (ICBME), 2012 19th Iranian Conference of
Conference_Location
Tehran, Iran
Print_ISBN
978-1-4673-3128-9
Type
conf
DOI
10.1109/ICBME.2012.6519669
Filename
6519669
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