Title :
Size effect of silica nanorattles on subacute toxicity in vivo
Author :
Tianlong Liu ; Linlin Li ; Huiyu Liu ; Changhui Fu ; Dong Chen ; Fangqiong Tang
Author_Institution :
Lab. of Controllable Preparation & Applic. of Nanomater., Tech. Inst. of Phys. & Chem., Beijing, China
Abstract :
In the present study, the repeated dose toxicities of three-sized 70, 110 and 260 nm SNs were demonstrated after intravenous injection in mice. ALT and AST were elevated in three-sized SN treated mice at 50 mg/kg, however, levels in vehicle and 5 mg/kg were comparably low. Histological analysis revealed lymphocytic infiltration and silicotic nodular like lesion in liver of high-dose SNs treated mice. Collagen fibers were observed around the silicotic nodular lesion, and hydroxyproline in liver increased dramatically. Serum biochemical index and morphological changes showed hepatotoxicity of SNs followed dose-dependent relationship.
Keywords :
biochemistry; biomedical materials; liver; molecular biophysics; molecular configurations; nanomedicine; nanoparticles; patient treatment; proteins; silicon compounds; toxicology; ALT; AST; SiO2; collagen fibers; dose toxicities; histological analysis; hydroxyproline; liver; lymphocytic infiltration; mice; serum biochemical index; serum morphology; silica nanorattle hepatotoxicity; silica nanorattle injection; silica nanorattle size effect; silicotic nodular lesion; size 110 nm; size 260 nm; size 70 nm; subacute toxicity in vivo; Size effect; safety; silica nanorattles; subacute toxicity;
Conference_Titel :
Nanotechnology Materials and Devices Conference (NMDC), 2012 IEEE
Conference_Location :
Waikiki Beach, HI
Print_ISBN :
978-1-4673-2871-5
DOI :
10.1109/NMDC.2012.6527592
