Title :
Separation of Ferucarbotran: A leading candidate of MPI tracer for practical use
Author :
Nohara, S. ; Kato, Ippei ; Ito, Yu ; Honma, T. ; Ishihara, Yoshiyuki
Author_Institution :
Meito Sangyo Co., Ltd., Japan
Abstract :
It is well known that the possibility of use of Resovist® as a tracer for MPI has been studied, but whose performance using a practicable MPI device is not adequate. In this situation, it has been suggested that the fractionation of Resovist® shows good performance than Resovist® itself1,2,3). Meito Sangyo has been manufacturing Ferucarbotran, an active pharmaceutical ingredients (API) for Resovist®, since 2001, and are studying to obtain a practicable MPI tracer by separation of Ferucarbotran. Here, we report the physical properties such as MPI signal, particle size, T2 relaxivity and the biological behavior of the fractions from Ferucarbotran.
Keywords :
biomedical materials; biomedical measurement; magnetic particles; nanomedicine; nanoparticles; pharmaceuticals; MPI signal; MPI tracer; Resovist fractionation; T2 relaxivity; active pharmaceutical ingredients; biological behavior; ferucarbotran separation; particle size; practical MPI device; Blood; Imaging; Kinetic theory; Magnetic cores; Magnetic separation; Performance evaluation;
Conference_Titel :
Magnetic Particle Imaging (IWMPI), 2013 International Workshop on
Conference_Location :
Berkeley, CA
Print_ISBN :
978-1-4673-5520-9
Electronic_ISBN :
978-1-4673-5521-6
DOI :
10.1109/IWMPI.2013.6528339
