Role of biofunctionalization and tracer cross-linking in magnetic particle spectrometry

Author

Arami, H. ; Ferguson, Richard Matthew ; Khandhar, A.P. ; Tomitaka, A. ; Krishnan, Kannan M.

Author_Institution

Dept. of Mater. Sci., Univ. of Washington, Seattle, WA, USA

fYear

2013

fDate

23-24 March 2013

Firstpage

1

Lastpage

1

Abstract

In this paper, we present a ligand exchange and PEGylation approach for developing monodisperse MPI tracers (core size ~ 20nm) with the required reactive -NH₂ and/or -SH functional groups on their surface. First, free carboxyl groups were introduced on the surface of the NPs through a silanization reaction. Then, a carbodiimide reagent (DCC) was used to bond the amine groups of the NH₂-PEG-NH₂ or NH₂-PEG-SH molecules to these carboxyl groups.

Keywords

biomagnetism; exchange interactions (electron); magnetic particles; molecular biophysics; nanomagnetics; nanoparticles; proteins; spectrochemical analysis; PEGylation approach; amine groups; biofunctionalization; carbodiimide reagent; carboxyl groups; core size; free carboxyl groups; ligand exchange; magnetic particle spectrometry; monodisperse MPI tracers; reactive NH₂ functional groups; reactive SH functional groups; silanization reaction; tracer cross-linking; Cancer; Hydrodynamics; Imaging; Magnetic cores; Magnetic particles; Nanobioscience; Spectroscopy;

fLanguage

English

Publisher

ieee

Conference_Titel

Magnetic Particle Imaging (IWMPI), 2013 International Workshop on

Conference_Location

Berkeley, CA

Print_ISBN

978-1-4673-5520-9

Electronic_ISBN

978-1-4673-5521-6

Type

conf

DOI

10.1109/IWMPI.2013.6528378

Filename

6528378