An efficient time-based CMOS potentiostat for neurotransmitters sensing

A time-based potentiostat measuring electrochemical redox currents is described for the detection and quantification of neurotransmitters. The CMOS potentiostat is controlled by an adaptive sampling algorithm to increase power efficiency, input dynamic range and sampling frequency. The integrated circuit is characterized through post-layout simulation, using 0.13 μm CMOS technology. Results show a 94 dB dynamic range, a minimum sampling frequency of 1.25 kHz and a minimum analog power consumption of 13 μW per channel. The proposed electrochemical sensor is suitable for neurochemical in-vivo monitoring specifications.