Title :
Magnetic nanotherapeutics of Guerin carcinoma
Author :
Orel, V.E. ; Nikolov, N.A. ; Rykhalskiy, A.Y. ; Dzyatkovskya, N.N. ; Romanov, A.V. ; Yaroshenko, O.Yu. ; Supruniuk, D. ; Orel, V.B. ; Khamrovskiy, M.M. ; Penievskyi, M.I. ; Radaguz, A.V.
Author_Institution :
Med. Phys. & Bioeng. Dept., Nat. Cancer Inst., Kiev, Ukraine
Abstract :
The research of animals with Guerin carcinoma has shown, that magneto-mechano-chemically synthesized magnetic nanocomplex on the basis of Fe3O4 nanoparticles with antitumor anthracycline row antibiotic doxorubicin and next local electromagnetic irradiation by spatially inhomogeneous constant magnetic and variable electromagnetic fields had a greater antitumor effect than conventional doxorubicin and magnetomechano-chemically synthesized magnetic nanocomplex without electromagnetic irradiation.
Keywords :
biological effects of fields; biomagnetism; cancer; drugs; iron compounds; magnetic particles; nanomedicine; nanoparticles; tumours; Fe3O4; Fe3O4 nanoparticles; Guerin carcinoma; antitumor anthracycline row antibiotic doxorubicin; antitumor effect; conventional doxorubicin; local electromagnetic irradiation; magnetic nanotherapeutics; magneto-mechano-chemically synthesized magnetic nanocomplex; spatially inhomogeneous constant magnetic fields; variable electromagnetic fields; Magnetic flux; Magnetic separation; Magnetomechanical effects; Magnetostatics; Saturation magnetization; Tumors; electromagnetic field; magnetic nanocomplex; magnetic-dipole applicator; tumor;
Conference_Titel :
Electronics and Nanotechnology (ELNANO), 2013 IEEE XXXIII International Scientific Conference
Conference_Location :
Kiev
Print_ISBN :
978-1-4673-4669-6
DOI :
10.1109/ELNANO.2013.6552027