DocumentCode :
617592
Title :
X-ray differential phase contrast and dark-field computed tomography and radiography with microbubbles as contrast agent
Author :
Xiangyang Tang ; Yi Yang
Author_Institution :
Sch. of Med., Dept. of Radiol. & Imaging Sci., Emory Univ., Atlanta, GA, USA
fYear :
2013
fDate :
7-11 April 2013
Firstpage :
1248
Lastpage :
1251
Abstract :
Motivated to improve the low contrast detectability of x-ray imaging in soft tissues, increasing effort has been devoted to the research and development of refraction-based x-ray phase contrast imaging. Among all existing implementations, the x-ray tube and grating based differential phase contrast imaging is of high potential to become an imaging modality for preclinical and eventually clinical applications. Based on our preliminary investigation and recognizing the clinical success of iodine contrast agent in conventional attenuation-based x-ray imaging, we propose the grating-based x-ray differential phase contrast and dark-field imaging method with microbubbles as the contrast agent. Via computer simulation, we investigate the feasibility of the proposed x-ray differential phase contrast and dark-field computed tomography in this work. Preliminary data show that at the detector cell dimension adequate for both clinical (>100μm) and preclinical (≤100μm) applications, the contrast between microbubbles and soft tissues in x-ray differential phase contrast and dark-field computed tomography images is substantially larger than its counterpart in the conventional attenuation-based CT, which encourages further in-depth investigation along this scientific and technological avenue.
Keywords :
X-ray tubes; biological tissues; bubbles; computerised tomography; diagnostic radiography; iodine; medical image processing; X-ray differential phase contrast; X-ray tube; attenuation-based computed tomography; computer simulation; contrast agent; conventional attenuation based X-ray imaging; dark-field computed tomography; detector cell dimension; grating based differential phase contrast imaging; imaging modality; iodine contrast agent; low-contrast detectability; microbubbles; radiography; refraction-based X-ray phase contrast imaging; soft tissues; Attenuation; Computed tomography; Detectors; Gratings; Image reconstruction; X-ray imaging; CT; contrast agent; microbubbles; x-ray dark-field CT; x-ray dark-field radiography; x-ray differential phase contrast CT; x-ray phase CT;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Biomedical Imaging (ISBI), 2013 IEEE 10th International Symposium on
Conference_Location :
San Francisco, CA
ISSN :
1945-7928
Print_ISBN :
978-1-4673-6456-0
Type :
conf
DOI :
10.1109/ISBI.2013.6556757
Filename :
6556757
Link To Document :
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