Title :
In-vitro sub-cellular sampling of metabolites in biological samples
Author :
Raghu, Deepa ; Qi Xia ; Linwen Zhang ; Vertes, Akos ; Reeves, Mark
Author_Institution :
Dept. of Phys., George Washington Univ., Washington, DC, USA
Abstract :
Chemical analysis of metabolites directly from cell samples at sub-cellular level in ambient conditions is essential to understand the biochemical pathways in these organisms. In order to achieve this goal we combine near-field ablation with mass spectrometry. As a first step towards the integration of near-field ablation with mass spectrometry, we will report preliminary results of the chemical analysis of Arabidopsis Thaliana.
Keywords :
biochemistry; biological specimen preparation; cellular biophysics; chemical analysis; mass spectroscopy; Arabidopsis Thaliana; biochemical pathways; biological samples; cell samples; chemical analysis; in-vitro subcellular sampling; mass spectrometry; metabolites; near-field ablation; Distribution functions; Graphical models; Ionization; Laser ablation; Mass spectroscopy; Materials; Metabolomics;
Conference_Titel :
Microsystems for Measurement and Instrumentation (MAMNA), 2013
Conference_Location :
Gaithersburg, MD
Print_ISBN :
978-1-4799-0221-7
DOI :
10.1109/MAMNA.2013.6557232
