Synthesis of antibacterial TiO2/PLGA composite biofilms

Author

Jau-Yi Wu ; Ching-Wen Li ; Ching-Hsiu Tsai ; Gou-Jen Wang

Author_Institution

Grad. Inst. of Biomed. Eng., Nat. Chung-Hsing Univ., Taichung, Taiwan

fYear

2013

fDate

7-10 April 2013

Firstpage

98

Lastpage

103

Abstract

The main purpose of this study was to develop a TiO₂/PLGA composite biomaterial for artificial dressing applications. E. coli and S. aureus were used as biological indicators for the disinfection efficiency of the proposed TiO₂/PLGA composite. Various concentration ratios of TiO₂ verse PLGA were implemented to optimize the disinfection efficiency of the composite biomaterial. Cell seedings of BECs and L929s on the TiO₂/PLGA composite biomaterial are further conducted to evaluate the feasibility of the TiO₂/PLGA composite biomaterial on wound healing applications. Experimental results illustrated that TiO₂/PLGA composite biofilms containing 10% of TiO₂ nanoparticles revealed an effective antibacterial property but kept a comparatively low suppression on cell growth.

Keywords

antibacterial activity; biomedical materials; cellular biophysics; composite materials; polymers; titanium compounds; wounds; BEC; E. coli; L929; S. aureus; TiO₂; antibacterial TiO2/PLGA composite biofilms; artificial dressing applications; biological indicators; cell growth; cell seedings; composite biomaterial; disinfection efficiency; synthesis; wound healing applications; Antibacterial activity; Biomembranes; Implants; Microorganisms; Nanobioscience; Nanoparticles; Wounds; TiO2/PLGA composite material; Titanium dioxide; antibacterial material;

fLanguage

English

Publisher

ieee

Conference_Titel

Nano/Micro Engineered and Molecular Systems (NEMS), 2013 8th IEEE International Conference on

Conference_Location

Suzhou

Electronic_ISBN

978-1-4673-6351-8

Type

conf

DOI

10.1109/NEMS.2013.6559690

Filename

6559690