Title :
Synthesis of antibacterial TiO2/PLGA composite biofilms
Author :
Jau-Yi Wu ; Ching-Wen Li ; Ching-Hsiu Tsai ; Gou-Jen Wang
Author_Institution :
Grad. Inst. of Biomed. Eng., Nat. Chung-Hsing Univ., Taichung, Taiwan
Abstract :
The main purpose of this study was to develop a TiO2/PLGA composite biomaterial for artificial dressing applications. E. coli and S. aureus were used as biological indicators for the disinfection efficiency of the proposed TiO2/PLGA composite. Various concentration ratios of TiO2 verse PLGA were implemented to optimize the disinfection efficiency of the composite biomaterial. Cell seedings of BECs and L929s on the TiO2/PLGA composite biomaterial are further conducted to evaluate the feasibility of the TiO2/PLGA composite biomaterial on wound healing applications. Experimental results illustrated that TiO2/PLGA composite biofilms containing 10% of TiO2 nanoparticles revealed an effective antibacterial property but kept a comparatively low suppression on cell growth.
Keywords :
antibacterial activity; biomedical materials; cellular biophysics; composite materials; polymers; titanium compounds; wounds; BEC; E. coli; L929; S. aureus; TiO2; antibacterial TiO2/PLGA composite biofilms; artificial dressing applications; biological indicators; cell growth; cell seedings; composite biomaterial; disinfection efficiency; synthesis; wound healing applications; Antibacterial activity; Biomembranes; Implants; Microorganisms; Nanobioscience; Nanoparticles; Wounds; TiO2/PLGA composite material; Titanium dioxide; antibacterial material;
Conference_Titel :
Nano/Micro Engineered and Molecular Systems (NEMS), 2013 8th IEEE International Conference on
Conference_Location :
Suzhou
Electronic_ISBN :
978-1-4673-6351-8
DOI :
10.1109/NEMS.2013.6559690
