Implantable CNT-based sensor for chondroitin sulfate proteoglycans detection of glial scar after spinal cord injury

The implantable CNT-based sensor is suggested to detect CSPGs which is main compositions of glial scar which inhibit the axonal regeneration after spinal cord injury. The suggested sensor is fabricated using spin-coated polyimide and patterned by MEMS process. Multiwalled CNT networks are formed by air spray method on the interdigitated sensor electrodes as the sensing element of CSPGs. The feasibility of the fabricated sensor is successfully confirmed in vitro by measuring the resistance change of CNT networks versus various CSPGs concentrations. The results show that the suggested sensor accurately detects the low CSPGs concentration to sense the regeneration-inhibitory effect of CSPGs.