Title :
Ambient pressure dependence of the subharmonic signal from ultrasound contrast microbubbles
Author :
Fei Li ; Tao Ling ; Chengrui Liu ; Qiaofeng Jin ; Feiyan Cai ; Hairong Zheng ; Deyu Li
Author_Institution :
Sch. of Biol. Sci. & Med. Eng., Beihang Univ., Beijing, China
Abstract :
Ultrasound contrast agents (UCA) microbubbles have been well recognized as a potential noninvasive tool for blood pressure measurement. The effect of ambient pressure on UCA subharmonic optimal driving frequency (SODF), at which the subharmonic scattering signals were maximal, was investigated experimentally. For groups of microbubbles with 80.1%±1.6% in the diameter range of 1μm-2μm, the shift of the SODF (SSODF) was 0.6MHz between overpressures of 4mmHg and 100mmHg, which was approximately twice of the corresponding shift of the resonance frequency. The SSODF may be as a novel and sensitive index of the local blood pressure estimation based on UCA microbubbles.
Keywords :
biomedical ultrasonics; blood pressure measurement; bubbles; SSODF; UCA microbubble; UCA subharmonic optimal driving frequency; ambient pressure dependence; blood pressure measurement; diameter range; frequency 0.6 MHz; local blood pressure estimation; pressure 100 mm Hg; pressure 4 mm Hg; resonance frequency shift; shift of the SODF; size 1 mum to 2 mum; subharmonic scattering signal; ultrasound contrast agent microbubble; Acoustic measurements; Acoustics; Blood pressure; Estimation; Resonant frequency; Ultrasonic imaging; Ultrasonic variables measurement; microbubble; pressure estimation; subharmonic; ultrasound;
Conference_Titel :
Ultrasonics Symposium (IUS), 2012 IEEE International
Conference_Location :
Dresden
Print_ISBN :
978-1-4673-4561-3
DOI :
10.1109/ULTSYM.2012.0165
