Title :
Low Temperature Plasma Causes Double-Strand Break DNA Damage in Primary Epithelial Cells Cultured From a Human Prostate Tumor
Author :
Hirst, Adam M. ; Frame, Fiona M. ; Maitland, Norman J. ; O´Connell, Dan
Author_Institution :
Dept. of Phys. & Biol., Univ. of York, York, UK
Abstract :
Research in the new field of plasma medicine continues to demonstrate the efficacy of low temperature plasmas (LTPs) for numerous biomedical applications. Responses such as reduction in cell viability and cell death for cancer therapy, cell proliferation for wound healing, and bacterial inactivation have been observed as a result of plasma treatment. In this paper, we applied LTP to prostate cancer primary cells derived from patient tumour tissue to inflict irreparable DNA damage.
Keywords :
DNA; cancer; cellular biophysics; microorganisms; molecular biophysics; plasma applications; radiation therapy; tumours; wounds; LTP; bacterial inactivation; biomedical applications; cancer therapy; cell death; cell proliferation; cell viability; double-strand break DNA damage; human prostate tumor; irreparable DNA damage; low-temperature plasma; patient tumour tissue; plasma medicine; plasma treatment; primary epithelial cells; prostate cancer primary cells; wound healing; Cancer; Cells (biology); DNA; Plasma temperature; Principal component analysis; Tumors; Atmospheric pressure plasma; DNA; cells (biology); oncology;
Journal_Title :
Plasma Science, IEEE Transactions on
DOI :
10.1109/TPS.2014.2351453
