DocumentCode :
620799
Title :
Ultrasonic transport of particles into articular cartilage and subchondral bone
Author :
Nieminen, H.J. ; Herranen, T. ; Kananen, V. ; Hacking, S.A. ; Salmi, Ahmed ; Karppinen, Pasi ; Hoggstrom, E.
Author_Institution :
Dept. of Phys., Univ. of Helsinki, Helsinki, Finland
fYear :
2012
fDate :
7-10 Oct. 2012
Firstpage :
1869
Lastpage :
1872
Abstract :
Osteoarthritis (OA) is a debilitating musculoskeletal disease without a cure. Delivery of therapeutic compounds is a problem and localized drug therapy could enable new treatment strategies. In this study high-intensity ultrasound was used to deliver micro- and nano-particles (MNPS) into three bovine osteochondral samples: (1) control (C) that was exposed to the particles without sonication, (2) UST-1 that was sonicated prior to immersion in a MNPS and (3) UST-2 that was sonicated in the presence of MNPS. Following treatment samples were cut into 2.9 ± 0.3 mm sections and digital images were obtained by light microscopy. In the sonicated samples (UST-1 and UST-2) MNPS penetrated into articular cartilage and subchondral bone. No MNPS penetration was observed in C. The proposed technique could potentially be used for local drug treatment of OA.
Keywords :
biological tissues; biomedical ultrasonics; diseases; drug delivery systems; drugs; nanomedicine; MNPS immersion; articular cartilage; bovine osteochondral samples; debilitating musculoskeletal disease; digital images; high intensity ultrasound; light microscopy; localized drug therapy; microparticle delivery; nanoparticle delivery; osteoarthritis; sonicated osteochondral samples; sonicated samples; subchondral bone; therapeutic compound delivery; ultrasonic particle transport; Acoustics; Bones; Joints; Microscopy; Protocols; Surface treatment; Ultrasonic imaging;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Ultrasonics Symposium (IUS), 2012 IEEE International
Conference_Location :
Dresden
ISSN :
1948-5719
Print_ISBN :
978-1-4673-4561-3
Type :
conf
DOI :
10.1109/ULTSYM.2012.0469
Filename :
6562164
Link To Document :
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