Title :
Multifunction intravascular ultrasound for microbubble based drug delivery
Author :
Kilroy, Joseph P. ; Hossack, John A. ; Klibanov, Alexander L. ; Wamhoff, Brian R.
Author_Institution :
Joseph P. Kilroy & John A. Hossack Dept. of Biomed. Eng., Univ. of Virginia, Charlottesville, VA, USA
Abstract :
A compact, single element, mechanically rotated intravascular ultrasound (IVUS) transducer for microbubble-based drug delivery and imaging has been designed and fabricated. This device provides displacement, delivery, and imaging capabilities to enable microbubble-based delivery of a therapeutic drug and delivery verification. The IVUS transducer was designed and fabricated to operate at a center frequency of 7 MHz. Acoustic radiation radiation force displacement of microbubbles, fluorophore delivery using microbubbles in vitro and imaging capabilities were demonstrated. Finally, a fluorescent model drug was delivered under physiological flow conditions to an ex vivo porcine artery using the prototype IVUS.
Keywords :
biomedical transducers; biomedical ultrasonics; blood vessels; bubbles; drug delivery systems; drugs; fluorescence; haemodynamics; physiology; ultrasonic imaging; ultrasonic transducers; acoustic radiation force displacement; compact intravascular ultrasound transducer; delivery verification; ex vivo porcine artery; fluorescent model drug; fluorophore delivery; frequency 7 MHz; mechanically rotated intravascular ultrasound transducer; microbubble-based drug delivery; microbubble-based drug imaging; multifunction intravascular ultrasound; physiological flow conditions; single element intravascular ultrasound transducer; therapeutic drug; Acoustics; Arteries; Drug delivery; Force; Imaging; Transducers; Ultrasonic imaging; Intravascular ultrasound; Microbubbles; Therapeutic ultrasound; Transducers;
Conference_Titel :
Ultrasonics Symposium (IUS), 2012 IEEE International
Conference_Location :
Dresden
Print_ISBN :
978-1-4673-4561-3
DOI :
10.1109/ULTSYM.2012.0541
