Title :
Modeling of neuromuscular blockade in general anesthesia
Author :
Hodrea, Ramona ; Morar, Radu ; Nascu, Ioana ; Vasian, Horatiu
Author_Institution :
Autom. Dept., Tech. Univ. of Cluj-Napoca, Cluj-Napoca, Romania
Abstract :
Neuromuscular blocking agents (NMBA) play an important role in anesthesia, although they do not provide any pain relief or produce unconsciousness. A Wiener model developed for neuromuscular blockade, using input-output data recorded during surgical interventions at Regional Institute of Gastroenterology and Hepatology "Prof. Dr. Octavian Fodor” Cluj-Napoca is presented in this paper. The model consists of a 3rd order transfer function and a nonlinear static model. A nominal model was obtained and the linear part was reduced from third order to second order. The model can be used further in a model-based predictive control strategy.
Keywords :
drugs; muscle; neurophysiology; physiological models; stochastic processes; surgery; NMBA modeling; Regional Institute of Gastroenterology and Hepatology; Wiener model; anesthesia; input-output data recording; model-based predictive control strategy; neuromuscular blocking agent; nonlinear static model; pain relief; surgical intervention; third-order transfer function; Data models; Drugs; Mathematical model; Neuromuscular; Predictive models; Transfer functions; Wiener model; identification; neuromuscular blockade;
Conference_Titel :
Advanced Topics in Electrical Engineering (ATEE), 2013 8th International Symposium on
Conference_Location :
Bucharest
Print_ISBN :
978-1-4673-5979-5
DOI :
10.1109/ATEE.2013.6563420