Title :
Exploring Model Integration through Quantized Information Flow
Author_Institution :
Ted Rogers Sch. of ITM, Ryerson Univ., Toronto, ON, Canada
Abstract :
The paper explores the integration of coarse-grained model abstractions using feedback of quantized information flow. The modeling and simulation of the lytic induction cycle of lambda phage is used as an illustrative example. The simulation results show that the model, with its modest complexity, has the capacity to internalize the relevant transcription regulatory logic and replicate the salient dynamics of the lytic induction cycle.
Keywords :
cellular biophysics; microorganisms; coarse-grained model abstraction; lambda phage; lytic induction cycle; model integration; quantized information flow; transcription regulatory logic; Analytical models; Biological system modeling; Computational modeling; Mathematical model; Protein engineering; Proteins; Coarse-grained Abstraction; Hierarchical Feedback; Quantized Information Flow;
Conference_Titel :
Bioengineering Conference (NEBEC), 2013 39th Annual Northeast
Conference_Location :
Syracuse, NY
Print_ISBN :
978-1-4673-4928-4
DOI :
10.1109/NEBEC.2013.94