Near Infrared Spectroscopy as a Method for Non-Destructive Monitoring of Engineered Cartilage Growth

Author

Shockley, Michael ; McGoverin, Cushla ; Palukuru, Uday ; Glenn, Padraig ; Pleshko, Nancy ; Spencer, Richard H.

Author_Institution

Dept. of Bioeng., Temple Univ., Philadelphia, PA, USA

fYear

2013

fDate

5-7 April 2013

Firstpage

51

Lastpage

52

Abstract

Tissue engineering is complicated by the plethora of factors which may influence the growth of tissue constructs. The potential of near infrared spectroscopy for the non-destructive periodic monitoring of engineered cartilage constructs was investigated. Spectral changes attributed to increased collagen and proteoglycan and decreased polyglycolic acid content were observed and were correlated to physical parameters of developing cartilage.

Keywords

biochemistry; biological tissues; infrared spectra; molecular biophysics; patient monitoring; proteins; spectrochemical analysis; tissue engineering; collagen; engineered cartilage growth; near infrared spectroscopy; nondestructive periodic monitoring; physical parameters; polyglycolic acid content; proteoglycan; spectral changes; tissue construct growth; tissue engineering; Calibration; Electronics packaging; Monitoring; Principal component analysis; Probes; Spectroscopy; Tissue engineering; articular cartilage; collagen and matrix proteins; proteoglycans; tissue engineering;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference (NEBEC), 2013 39th Annual Northeast

Conference_Location

Syracuse, NY

ISSN

2160-7001

Print_ISBN

978-1-4673-4928-4

Type

conf

DOI

10.1109/NEBEC.2013.119

Filename

6574352