Title :
Near Infrared Spectroscopy as a Method for Non-Destructive Monitoring of Engineered Cartilage Growth
Author :
Shockley, Michael ; McGoverin, Cushla ; Palukuru, Uday ; Glenn, Padraig ; Pleshko, Nancy ; Spencer, Richard H.
Author_Institution :
Dept. of Bioeng., Temple Univ., Philadelphia, PA, USA
Abstract :
Tissue engineering is complicated by the plethora of factors which may influence the growth of tissue constructs. The potential of near infrared spectroscopy for the non-destructive periodic monitoring of engineered cartilage constructs was investigated. Spectral changes attributed to increased collagen and proteoglycan and decreased polyglycolic acid content were observed and were correlated to physical parameters of developing cartilage.
Keywords :
biochemistry; biological tissues; infrared spectra; molecular biophysics; patient monitoring; proteins; spectrochemical analysis; tissue engineering; collagen; engineered cartilage growth; near infrared spectroscopy; nondestructive periodic monitoring; physical parameters; polyglycolic acid content; proteoglycan; spectral changes; tissue construct growth; tissue engineering; Calibration; Electronics packaging; Monitoring; Principal component analysis; Probes; Spectroscopy; Tissue engineering; articular cartilage; collagen and matrix proteins; proteoglycans; tissue engineering;
Conference_Titel :
Bioengineering Conference (NEBEC), 2013 39th Annual Northeast
Conference_Location :
Syracuse, NY
Print_ISBN :
978-1-4673-4928-4
DOI :
10.1109/NEBEC.2013.119
