Title :
Multimodal Polymeric Contrast Agents
Author :
Teraphongphom, Nutte Tarn ; Wheatley, Margaret A. ; Chhour, Peter ; Cormode, David P.
Author_Institution :
Drexel Univ., Philadelphia, PA, USA
Abstract :
Ultrasound Contrast Agents (UCA) are microencapsulated gas bubbles used to increase the overall contrast of the ultrasound (US) image. Novel multimodal polymeric UCA containing additional contrast agents that are active in multiple imaging modalities have been developed. Three platforms of loaded poly (lactic acid) (PLA) shelled UCA are presented. The first two platforms co-encapsulate aqueous or organic Quantum Dots (QD). The Third platform contains magnetic iron oxide nanoparticles (MNP). All platforms showed that the properties of UCA are maintained as well as the properties of additional encapsulated contrast agent. This study explores the potential application for improving the screening of a subject using at least two different modalities, e.g. ultrasound and magnetic resonance imaging.
Keywords :
biomedical ultrasonics; encapsulation; nanomedicine; nanoparticles; polymers; quantum dots; FeO; MNP; PLA shelled UCA; UCA properties; US image contrast; additional encapsulated contrast agent properties; aqueous quantum dot coencapsulation; loaded poly (lactic acid); magnetic iron oxide nanoparticle; magnetic resonance imaging; microencapsulated gas bubble; multimodal polymeric UCA; multimodal polymeric contrast agent; multiple imaging modality contrast agent; organic QD coencapsulation; screening improvement; ultrasound contrast agent; ultrasound imaging; In vitro; Magnetic resonance imaging; Magnetoacoustic effects; Programmable logic arrays; Scanning electron microscopy; Surface morphology; Magnetic Iron Oxide; Microbubble; Multimodal; Nanoparticle; Quantum Dots; Ultrasound Contrast Agent;
Conference_Titel :
Bioengineering Conference (NEBEC), 2013 39th Annual Northeast
Conference_Location :
Syracuse, NY
Print_ISBN :
978-1-4673-4928-4
DOI :
10.1109/NEBEC.2013.114
