Bi-functionnal Pepides to Promote Epithelial Sealing on Ti and Ti6Al4V

Dental implant stability is dependent of the quality of the epithelial sealing around abutment. We developed bi-functional peptides as linkers between cell and metal. Metal specific 12-mer peptides were selected by phage display and their adhesion forces to implant surfaces investigated by Atomic force microscopy (AFM). On these two peptides cell specific sequences were added in order to synthetize four bi-functional peptides AFM single cell force spectroscopy show the functional characteristics of the four peptides in culture media conditions. This in-vitro study suggests that bi-functional peptides are good candidates to enhance epithelial sealing on implant abutments.