Title :
Incorporation of flux balance analysis in pre-β-oxidation network to detect carnitine translocase in the cardiac cell in homo sapiens
Author :
Vijayaragahavan, Tarika ; Tagore, Somnath
Author_Institution :
Dept. of Biotechnol. & Bioinf., Padmashree Dr. D.Y. Patil Univ., Navi Mumbai, India
Abstract :
Fats are immensely important for the survival of the human body. These are stored in the body in the form of fatty acids and reused whenever the body is unable to consume essential fats(at the time of exercise, fasting etc). In the human heart cell, the transport of certain fatty acids into the mitochondria is required to produce energy. This is done via a certain enzyme called Carnitine Translocase. This paper emphasizes on the simulation of the presence of Carnitine Translocase. Metabolic flux balance analysis was done to detect the presence of this enzyme, thus by preventing the accumulation of excess Fatty Acyl Carnitine that is known to give rise to various Cardiovascular diseases such as hypoglycemia, arrhythmia etc.
Keywords :
biochemistry; cardiovascular system; cellular biophysics; diseases; enzymes; molecular biophysics; oxidation; Carnitine Translocase detection; Fatty Acyl Carnitine; Homo sapiens; cardiac cell; cardiovascular disease; enzyme detection; fatty acid transportation; human heart cell; metabolic flux balance analysis; mitochondria; pre-β- oxidation network; Biochemistry; Biomembranes; Equations; Heart; Linear programming; Mathematical model; Microelectronics; CPT; Carnitine Translocase; Carnitine shuttle; Fatty acids; Flux Balance Analysis; Malonyl-CoA;
Conference_Titel :
Emerging Research Areas and 2013 International Conference on Microelectronics, Communications and Renewable Energy (AICERA/ICMiCR), 2013 Annual International Conference on
Conference_Location :
Kanjirapally
Print_ISBN :
978-1-4673-5150-8
DOI :
10.1109/AICERA-ICMiCR.2013.6576008