Title :
Synthesis of hierarchical porous bioactive glasses for bone tissue regeneration
Author :
Jie Ma ; Huiming Lin ; Xiaofeng Li ; Chunhui Bian ; Di Xiang ; Fengyu Qu
Author_Institution :
Key Lab. of Design & Synthesis of Functional Mater. & Green Catalysis, Harbin Normal Univ., Harbin, China
Abstract :
A novel hierarchical porous bioactive glasses were synthesised with cattail stem and triblock polyethylene oxide-propylene oxide block copolymer (P123) as macroporous template and mesoporous template, respectively. The structural and textural properties of materials were characterised by X-ray diffraction, scanning electron microscope, Fourier transform infrared spectroscopy, nitrogen adsorption-desorption, energy dispersive spectrometer and vibrating sample magnetometer technique. The results reveal the bioglasses possess multilevel porous structure with the macroporous size about 50 μm and the mesopore with the diameter of 3.86 nm. Furthermore, metformin HCl was used as the model drug. The drug release kinetics and hydroxyapatite (HAP, (Ca10(PO4)6(OH)2)) inducing-growth ability of the composites were studied, respectively. The system exhibits the fast HAP inducing-growth ability and long-term drug delivery, making them a good candidate for bone tissue regeneration.
Keywords :
Fourier transform spectra; X-ray chemical analysis; X-ray diffraction; adsorption; bioceramics; bone; calcium compounds; desorption; drug delivery systems; drugs; infrared spectra; mesoporous materials; nanofabrication; nanomedicine; nanoporous materials; nitrogen; phosphate glasses; porosity; scanning electron microscopy; surface texture; tissue engineering; Ca10(PO4)6(OH)2; Fourier transform infrared spectroscopy; N2; P123; X-ray diffraction; bone tissue regeneration; cattail stem; drug release kinetics; energy dispersive spectrometer; hierarchical porous bioactive glasses; hydroxyapatite inducing-growth ability; long-term drug delivery; macroporous size; macroporous template; mesoporous template; metformin HCl; multilevel porous structure; nitrogen adsorption-desorption; scanning electron microscopy; size 3.86 nm; structural properties; textural properties; triblock polyethylene oxide-propylene oxide block copolymer P123; vibrating sample magnetometer;
Journal_Title :
Nanobiotechnology, IET
DOI :
10.1049/iet-nbt.2013.0054
