A 1024-channel CMOS microelectrode-array system with 26´400 electrodes for recording and stimulation of electro-active cells in-vitro

Author

Ballini, Marco ; Muller, Johannes ; Livi, Paolo ; Chen, Yuanfeng ; Frey, Urs ; Shadmani, Amir ; Jones, Ian Lloyd ; Gong, Wenyu ; Fiscella, Michele ; Radivojevic, Milos ; Bakkum, Douglas ; Stettler, Alexander ; Heer, Flavio ; Hierlemann, Andreas

Author_Institution

ETH Zurich, Basle, Switzerland

fYear

2013

fDate

12-14 June 2013

Abstract

We report on a CMOS microelectrode array system chip for recording and stimulation of electrogenic cell cultures and tissues, featuring a sensing area of 8.09 mm², composed of 26´400 electrodes at 17.5 μm pitch. A user-configurable selection of the electrodes can be routed to 32 stimulation units and to 1024 recording channels with 2.4 μVrms input-referred noise and 10-bit 20-kS/s A/D conversion. The system offers a versatile platform with excellent signal characteristics for a wide range of electrophysiological recordings.

Keywords

CMOS integrated circuits; bioelectric phenomena; biological tissues; biomedical electrodes; biomedical electronics; cellular biophysics; lab-on-a-chip; microelectrodes; CMOS microelectrode array system chip; electro active cells; electrodes; electrogenic cell cultures; electrophysiological recordings; user configurable selection; versatile platform; Arrays; CMOS integrated circuits; Electrodes; Neurons; Noise; Sensors; Spatial resolution;

fLanguage

English

Publisher

ieee

Conference_Titel

VLSI Circuits (VLSIC), 2013 Symposium on

Conference_Location

Kyoto

Print_ISBN

978-1-4673-5531-5

Type

conf

Filename

6578717