Optimal control of crystallization of alpha-lactose monohydrate

Author

Rachah, Amira ; Noll, Dominikus

Author_Institution

Inst. de Math., Univ. de Toulouse, Toulouse, France

fYear

2013

fDate

23-26 June 2013

Firstpage

1

Lastpage

6

Abstract

We present a mathematical model for solvated crystallization of a-lactose monohydrate in semi-batch mode. The process dynamics are governed by conservation laws including population, molar and energy balance equations. We present and discuss the model and then control the process with the goal to privilege the production of small particles in the range between 10^-5 and 10^-4μm. We compare several specific and unspecific cost functions leading to optimal strategies with significantly different effects on product quality. Control inputs are temperature, feed rate, and the choice of an appropriate crystal seed.

Keywords

conservation laws; crystal growth from solution; crystallisation; mathematical analysis; organic compounds; solvation; α-lactose monohydrate; alpha-lactose monohydrate; conservation laws; crystal seed; energy balance equations; feed rate; mathematical model; molar equations; optimal crystallization control; population equations; process dynamics; product quality; semibatch mode; small particles production; solvated crystallization; specific cost functions; temperature inputs; unspecific cost functions; Crystallization; Feeds; Mathematical model; Sociology; Statistics; Temperature control;

fLanguage

English

Publisher

ieee

Conference_Titel

Control Conference (ASCC), 2013 9th Asian

Conference_Location

Istanbul

Print_ISBN

978-1-4673-5767-8

Type

conf

DOI

10.1109/ASCC.2013.6606367

Filename

6606367