DocumentCode :
636246
Title :
Dictionary learning improves subtyping of breast cancer aCGH data
Author :
Masecchia, Salvatore ; Barla, Annalisa ; Salzo, Saverio ; Verri, Alessandro
Author_Institution :
DIBRIS, Univ. of Genova, Genoa, Italy
fYear :
2013
fDate :
3-7 July 2013
Firstpage :
604
Lastpage :
607
Abstract :
The advent of Comparative Genomic Hybridization (CGH) data led to the development of new mathematical models and computational methods to automatically infer chromosomal alterations. In this work we tackle a standard clustering problem exploiting the good representation properties of a novel method based on dictionary learning. The identified dictionary atoms, which show co-occuring shared alterations among samples, can be easily interpreted by domain experts. We compare a state-of-the-art approach with an original method on a breast cancer dataset.
Keywords :
biological organs; cancer; genomics; mathematical analysis; physiological models; CGH data; breast cancer dataaset; chromosomal alterations; comparative genomic hybridization data; computational methods; dictionary atoms; dictionary learning; mathematical models; standard clustering problem; state-of-the-art approach; Bioinformatics; Biological cells; Breast cancer; Dictionaries; Genomics; Tumors;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE
Conference_Location :
Osaka
ISSN :
1557-170X
Type :
conf
DOI :
10.1109/EMBC.2013.6609572
Filename :
6609572
Link To Document :
بازگشت