A hybrid model for the prediction of mRNA polyadenylation signals

The mRNA polyadenylation is the cellular process that adds adenosine tails to mature mRNAs. Malfunction of polyadenylation has been implicated in several human diseases. In this paper, we proposed a novel feature extraction approach which employs the K-gram nucleotide acid pattern, the position weight matrix (PWM) and the increment of diversity (ID) to represent the original features. Then Principle Component Analysis (PCA) was applied to transform the original features into a new feature space where the low-dimensional features were used to train the real-coded genetic neural network model. In the experiments, our proposed algorithm (GA-BP) can achieve the accuracy about 82.98%, specificity 82.95% and sensitivity 83.01% in the specific dataset constructed by Kalkatawi. The results demonstrate that GA-BP is a promising algorithm for the prediction of mRNA polyadenylation signals.