Title :
Physical stability of cholesterol derivatives combined with liposomes and their in vitro behavior
Author :
Bin Yang ; Sheng-Yong Geng ; Jin-Ye Wang
Author_Institution :
Sch. of Biomed. Eng., Shanghai Jiao Tong Univ., Shanghai, China
Abstract :
The purpose of this study was to investigate the physical stability and drug release of two cholesterol derivatives (4-cholesterocarbonyl-4´-(N,N,N-triethylamine butyloxyl bromide, CTBBA, and 4-cholesterocarbonyl-4´-(N,N´-diethylamino-butyloxy, CDBA), when combined with doxorubicin (DOX)-loaded liposomes in vitro. CTBBA-liposome revealed a positive charge at a pH between 3 and 10, as indicated by the ζ-potential. DOX-encapsulated CTBBA-liposomes possessed better physical stability both in PBS and in fetal bovine serum (FBS) added to PBS.
Keywords :
biomembrane transport; cellular biophysics; drug delivery systems; drugs; electrokinetic effects; molecular biophysics; organic compounds; pH; 4-cholesterocarbonyl-4´-(N,N´-diethylamino-butyloxy); 4-cholesterocarbonyl-4´-(N,N,N-triethylamine butyloxyl bromide); CDBA; DOX-encapsulated CTBBA-liposome; DOX-loaded liposome; PBS; cholesterol derivative-liposome combination; doxorubicin-loaded liposome; drug release; fetal bovine serum; in vitro behavior; pH; physical stability; positive charge; zeta-potential; Drug delivery; Drugs; Encapsulation; Lipidomics; Proteins; Suspensions; Thermal stability;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE
Conference_Location :
Osaka
DOI :
10.1109/EMBC.2013.6610450
