Title :
Automated measurement of cerebral cortical thickness based on fuzzy membership map derived from MR images for evaluation of Alzheimer´s disease
Author :
Arimura, H. ; Tokunaga, Carlos ; Yoshiura, Takahito ; Ohara, Tomoyuki ; Yamashita, Yukihiko ; Toyofuku, Fukai
Author_Institution :
Kyushu Univ., Fukuoka, Japan
Abstract :
We have proposed an automated method for three-dimensional (3D) measurement of cerebral cortical thicknesses based on fuzzy membership maps derived from magnetic resonance (MR) images for evaluation of Alzheimer´s disease (AD). The cerebral cortical thickness was three-dimensionally measured on each cortical surface voxel by using a localized gradient vector trajectory in a fuzzy membership map. The proposed method could be useful for the 3D measurement of the cerebral cortical thickness on individual cortical surface voxels as an atrophy feature in AD.
Keywords :
biomedical MRI; diseases; fuzzy set theory; medical image processing; neurophysiology; AD; Alzheimer´s disease evaluation; MR image; atrophy feature; automated measurement; cerebral cortical thickness; fuzzy membership map; individual cortical surface voxel; localized gradient vector trajectory; magnetic resonance image; three-dimensional measurement; Alzheimer´s disease; Atrophy; Brain modeling; Thickness measurement; Three-dimensional displays; Trajectory; Vectors;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE
Conference_Location :
Osaka
DOI :
10.1109/EMBC.2013.6611198
