Automated measurement of cerebral cortical thickness based on fuzzy membership map derived from MR images for evaluation of Alzheimer´s disease

Author

Arimura, H. ; Tokunaga, Carlos ; Yoshiura, Takahito ; Ohara, Tomoyuki ; Yamashita, Yukihiko ; Toyofuku, Fukai

Author_Institution

Kyushu Univ., Fukuoka, Japan

fYear

2013

fDate

3-7 July 2013

Firstpage

7116

Lastpage

7119

Abstract

We have proposed an automated method for three-dimensional (3D) measurement of cerebral cortical thicknesses based on fuzzy membership maps derived from magnetic resonance (MR) images for evaluation of Alzheimer´s disease (AD). The cerebral cortical thickness was three-dimensionally measured on each cortical surface voxel by using a localized gradient vector trajectory in a fuzzy membership map. The proposed method could be useful for the 3D measurement of the cerebral cortical thickness on individual cortical surface voxels as an atrophy feature in AD.

Keywords

biomedical MRI; diseases; fuzzy set theory; medical image processing; neurophysiology; AD; Alzheimer´s disease evaluation; MR image; atrophy feature; automated measurement; cerebral cortical thickness; fuzzy membership map; individual cortical surface voxel; localized gradient vector trajectory; magnetic resonance image; three-dimensional measurement; Alzheimer´s disease; Atrophy; Brain modeling; Thickness measurement; Three-dimensional displays; Trajectory; Vectors;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE

Conference_Location

Osaka

ISSN

1557-170X

Type

conf

DOI

10.1109/EMBC.2013.6611198

Filename

6611198