Analysis of hydration and dehydration on xanthine related compounds during pharmaceutical granulation process using terahertz spectroscopy

Author

Sakamoto, Takanori ; Sasaki, T. ; Kimura, Hiromitsu ; Hiyama, Yukio ; Katori, Noriko ; Okuda, Haruhisa

Author_Institution

Div. of Drugs, Nat. Inst. of Health Sci., Tokyo, Japan

fYear

2013

fDate

1-6 Sept. 2013

Firstpage

1

Lastpage

2

Abstract

Hydration and dehydration processes during a pharmaceutical granulation process of xanthine related compounds were investigated using terahertz/far-infrared, mid-infrared and near-infrared electromagnetic waves. Certain kinds of xanthine related compounds and binders gave hydration and/or dehydration.

Keywords

biochemistry; bioelectric phenomena; biomagnetism; dissociation; drugs; electromagnetic waves; infrared spectra; molecular biophysics; solvation; spectrochemical analysis; terahertz wave spectra; binders; dehydration; hydration; midinfrared electromagnetic waves; near-infrared electromagnetic waves; pharmaceutical granulation process; terahertz spectroscopy; terahertz-far-infrared electromagnetic waves; xanthine related compounds; Absorption; Atmospheric measurements; Compounds; Heating; Hydrogen; Pharmaceuticals; Temperature measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Infrared, Millimeter, and Terahertz Waves (IRMMW-THz), 2013 38th International Conference on

Conference_Location

Mainz

Type

conf

DOI

10.1109/IRMMW-THz.2013.6665549

Filename

6665549