Title :
Looking Deeper: Multimodal and contrast-enhanced photoacoustic imaging offer a clearer view within tissues for more accurate diagnosis.
Author :
Pramanik, Manojit ; Chulhong Kim
Author_Institution :
Sch. of Chem. & Biomed. Eng., Nanyang Technol. Univ., Singapore, Singapore
Abstract :
Optical imaging modalities such as fluorescence (FL) microscopy, multiphoton microscopy, and optical coherence tomography (OCT) have been well established for high optical contrast and high spatial resolution imaging of biological tissues. However, as they are dependent on ballistic photons, these methods fail to image beyond ~1 mm or so inside biological tissue. In contrast, diffuse optical imaging (DOI), which uses multiple scattered photons for imaging, can image much deeper (up to a several centimeters) into the tissue. Unfortunately, due to strong light scattering in tissues, it fails to maintain the high resolution at the deeper imaging depth. Photoacoustic imaging (PAI) bridges this gap of imaging deeper with high resolution and contrast by combining optical excitation with acoustic detection [1].
Keywords :
acoustic imaging; biological tissues; biomedical optical imaging; fluorescence; light scattering; multiphoton processes; optical microscopy; optical tomography; OCT; acoustic detection; ballistic photons; biological tissues; contrast-enhanced photoacoustic imaging; diagnosis; diffuse optical imaging; fluorescence microscopy; high optical contrast imaging; high spatial resolution imaging; light scattering; multimodal photoacoustic imaging; multiphoton microscopy; multiple scattered photons; optical coherence tomography; optical excitation; optical imaging modalities; Biomedical optical imaging; Optical imaging; Optical pulses; Optical scattering; Optical sensors; Photoacoustic effects;
Journal_Title :
Pulse, IEEE
DOI :
10.1109/MPUL.2015.2409101