Title :
A 50µm pitch, 1120-channel, 20kHz frame rate microelectrode array for slice recording
Author :
Johnson, Bryant ; Peace, Shane T. ; Cleland, Thomas A. ; Molnar, Adrienn
Author_Institution :
Sch. of Electr. & Comput. Eng, Cornell Univ., Ithaca, NY, USA
fDate :
Oct. 31 2013-Nov. 2 2013
Abstract :
We present a 1,120 channel active microelectrode array with 50μm pitch recording sites for direct recording of neural slices. Every sensor site has a frontend low noise amplifier and photopixel for correlating optical stimulus with electrical activity. The frontend is AC-coupled and achieves area-efficiency by integrating the large input capacitor and recording electrode directly over the circuitry in conjunction with a single T-capacitor feedback network. Degraded PSRR (63dB) and CMRR (21dB) from the single feedback network are overcome by utilizing a virtual shared reference, improving rejection to 84dB and 66dB, respectively. Despite a small area, the frontend amplifier has an input-referred noise of 4.3μVrms with tunable high- and low-pass corners with very little variation from site-to-site. Experiments from a transgenic mouse olfactory bulb slice are shown. The array was implemented in a standard 180nm CMOS process.
Keywords :
CMOS integrated circuits; bioelectric phenomena; biomedical electrodes; biomedical electronics; low noise amplifiers; microelectrodes; neurophysiology; AC-coupled frontend; CMOS process; T-capacitor feedback network; electrical activity; frequency 20 kHz; frontend low noise amplifier; microelectrode array; neural slices; optical stimulus; photopixel; size 180 nm; slice recording; transgenic mouse olfactory bulb slice; Arrays; Capacitors; Electrodes; Electronics packaging; Noise; Olfactory; Optical sensors;
Conference_Titel :
Biomedical Circuits and Systems Conference (BioCAS), 2013 IEEE
Conference_Location :
Rotterdam
DOI :
10.1109/BioCAS.2013.6679651