Title :
Multi-electrode amperometric biosensor for neurotransmitters detection
Author :
Massicotte, G. ; Sawan, Mohamad ; De Micheli, G. ; Carrara, Sandro
Author_Institution :
Polystim Neurotechnologies Lab., Polytech. Montreal, Montreal, QC, Canada
fDate :
Oct. 31 2013-Nov. 2 2013
Abstract :
Multi-target detection of neurochemicals is crucial to elucidate brain chemical signaling interplay. We describe in this paper an efficient experimental method to detect 2 types of neurotransmitters and the subsequent implementation of a dedicated potentiostat custom circuit. The experimental method is based on a biosensor performing constant-potential amperometry for an efficient detection of neurotransmitters, such as dopamine and glutamate, using a Carbon-nanotube (CNT)-based multi-working electrode sensor, which offers high sensitivity and selectivity. The custom CMOS time-based potentiostat circuit, designed to accommodate the detection of a wide variety of neurochemicals, is used as transducer. The proposed design is characterized through post-layout simulations, showing a wide dynamic input current range of 20 pA to 800 nA, and an input referred noise of 0.13 pA/√Hz. The circuit dissipates 56 μW for a minimum sampling frequency of 1.25 kHz. Circuit performances fully satisfies the requirements for the developed dopamine and glutamate sensors. The proposed biosensor configuration can be extended to the detection of a large number of neurochemicals.
Keywords :
CMOS integrated circuits; amperometric sensors; biochemistry; biomedical electrodes; biomedical electronics; biomedical transducers; biosensors; brain; neurophysiology; biosensor configuration; brain chemical signaling interplay; carbon-nanotube-based multiworking electrode sensor; constant-potential amperometry; current 20 pA to 800 nA; custom CMOS time-based potentiostat circuit; dopamine sensors; experimental method; glutamate sensors; multielectrode amperometric biosensor; multitarget detection; neurochemicals; neurotransmitters detection; post-layout simulations; potentiostat custom circuit; transducer; Biosensors; Electrodes; Frequency division multiplexing; Neurotransmitters; Noise; Oxidation; Sensitivity;
Conference_Titel :
Biomedical Circuits and Systems Conference (BioCAS), 2013 IEEE
Conference_Location :
Rotterdam
DOI :
10.1109/BioCAS.2013.6679664