Title :
Weighted averaging clustering algorithm for Haplotype Reconstruction Problem
Author :
Baharian, Ardeshir ; Heidari, Mortaza ; Salimi, Amir
Author_Institution :
Dept. of algorithms & Comput., Univ. of Tehran, Tehran, Iran
fDate :
Oct. 31 2013-Nov. 1 2013
Abstract :
The high cost and lack of accuracy in haplotypes sampling has caused it´s reconstruction problem enters the field of computer science as a laboratory genetic science case. Deducing haplotypes from SNP fragments which may have deficient and incorrect information, decreases laboratory costs. In this regard, various models have been presented as a NPHard problem such as MEC and MEC/GI. The MEC model used in this paper is basically a clustering problem and there are some solutions in this area. Here we have tried to decrease the data complexity, using fuzzy method of weighted averaging then the K-Means clustering method has been applied. As a result, the proficiency of the model has been proven by applying it in two real datasets.
Keywords :
biology computing; computational complexity; fuzzy set theory; pattern clustering; Haplotype reconstruction problem; MEC-GI model; NP-hard problem; SNP fragments; computer science; data complexity; fuzzy method; haplotype sampling; k-mean clustering method; laboratory genetic science; single nucleotide polymorphism; weighted averaging clustering algorithm; Biological system modeling; Education; Manganese; Open wireless architecture; K-Means algorithm; MEC model; SNP fragments; aggregation; data fusion; haplotype; reconstruction rate of haplotype; weighted averaging;
Conference_Titel :
Computer and Knowledge Engineering (ICCKE), 2013 3th International eConference on
Conference_Location :
Mashhad
Print_ISBN :
978-1-4799-2092-1
DOI :
10.1109/ICCKE.2013.6682801