DocumentCode
653866
Title
Weighted averaging clustering algorithm for Haplotype Reconstruction Problem
Author
Baharian, Ardeshir ; Heidari, Mortaza ; Salimi, Amir
Author_Institution
Dept. of algorithms & Comput., Univ. of Tehran, Tehran, Iran
fYear
2013
fDate
Oct. 31 2013-Nov. 1 2013
Firstpage
240
Lastpage
245
Abstract
The high cost and lack of accuracy in haplotypes sampling has caused it´s reconstruction problem enters the field of computer science as a laboratory genetic science case. Deducing haplotypes from SNP fragments which may have deficient and incorrect information, decreases laboratory costs. In this regard, various models have been presented as a NPHard problem such as MEC and MEC/GI. The MEC model used in this paper is basically a clustering problem and there are some solutions in this area. Here we have tried to decrease the data complexity, using fuzzy method of weighted averaging then the K-Means clustering method has been applied. As a result, the proficiency of the model has been proven by applying it in two real datasets.
Keywords
biology computing; computational complexity; fuzzy set theory; pattern clustering; Haplotype reconstruction problem; MEC-GI model; NP-hard problem; SNP fragments; computer science; data complexity; fuzzy method; haplotype sampling; k-mean clustering method; laboratory genetic science; single nucleotide polymorphism; weighted averaging clustering algorithm; Biological system modeling; Education; Manganese; Open wireless architecture; K-Means algorithm; MEC model; SNP fragments; aggregation; data fusion; haplotype; reconstruction rate of haplotype; weighted averaging;
fLanguage
English
Publisher
ieee
Conference_Titel
Computer and Knowledge Engineering (ICCKE), 2013 3th International eConference on
Conference_Location
Mashhad
Print_ISBN
978-1-4799-2092-1
Type
conf
DOI
10.1109/ICCKE.2013.6682801
Filename
6682801
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