Title :
Compact silicon biosensor for the clinical range estimation of blood serum triglycéride
Author :
Veeramani, M.S. ; Ratchagar, N.P. ; Bhattacharya, E. ; Pavan, Shanthi ; Prakash, Sachin ; Chadha, Anupama
Author_Institution :
Dept. of Electr. Eng., Indian Inst. of Technol. Madras, Chennai, India
Abstract :
Electrolyte Insulator Semiconductor Capacitor (El S CAP) is a transducer that can detect triglycerides (TGs) in blood serum through an enzymatic response that changes the pH of the electrolyte (blood serum). This change in pH is transformed by the EISCAP to a shift in the capacitance-voltage (C-V) characteristics of the device which in turn can be mapped to the amount of TG in blood serum. We have developed a miniaturized biochip with immobilized enzyme integrated with a thin film counter electrode for the estimation of TG in blood serum within the clinical range. The miniaturized devices are tested using blood serum sample to estimate the TG concentration and compared with clinical data.
Keywords :
bioelectric phenomena; biomedical electrodes; biomedical transducers; biosensors; blood; electrolytes; electrolytic capacitors; enzymes; lab-on-a-chip; molecular biophysics; pH; silicon; Si; blood serum triglyceride detection; capacitance-voltage characteristics; clinical data; clinical range estimation; compact silicon biosensor; electrolyte insulator semiconductor capacitor; immobilized enzyme; miniaturized biochip; pH; thin film counter electrode; transducer; Biochemistry; Biosensors; Blood; Electrodes; Sensitivity; Silicon;
Conference_Titel :
SENSORS, 2013 IEEE
Conference_Location :
Baltimore, MD
DOI :
10.1109/ICSENS.2013.6688212
