HIG — An in-memory database platform enabling real-time analyses of genome data

Costs and time required for sequencing of DNA and RNA declined through use of next generation sequencing technology, e.g. up to 30-times coverage reads are generated in less than two days. However, its interpretation and analysis is still a time-consuming process potentially taking weeks. In this work, we present a completely new architecture for processing and analyzing genome data. It builds on the in-memory database technology to eliminate time-consuming file-based data operations and to enable real-time data analysis. We found out that the use of in-memory technology as an integral component for genome data processing and its analysis significantly reduces time and costs to obtain relevant results, e.g. in the course of personalized medicine.