Focused and deep brain magnetic stimulation using new coil design in mice

Author

March, Stephen D. ; McAtee, S. ; Senter, Michael ; Spoth, Kristopher ; Stiner, Daniel R. ; Crowther, Lawrence J. ; Hadimani, Ravi L. ; Jiles, David C.

Author_Institution

Dept. of Electr. & Comput. Eng., Iowa State Univ., Ames, IA, USA

fYear

2013

fDate

6-8 Nov. 2013

Firstpage

125

Lastpage

128

Abstract

Deep brain transcranial magnetic stimulation (TMS) offers promising treatment for neurological disorders that originate from deeper regions of the brain, such as Parkinson´s disease. Coils designed for the human head need significant redesigning to stimulate selective regions of the mouse brain for advanced TMS therapy analysis. We report a focused and deep brain TMS coil for mice that is based on a two coil configuration similar to the “Halo coil”. A heterogeneous MRI derived head model of mouse was used to obtain an electric field of about 150 V/m in selective deeper regions of the brain. Focality of stimulation was quantified using the ratio of half value volume to half value of depth of electric field. A prototype of the final coil design was fabricated and characterized to compare simulated and physical magnetic field profiles.

Keywords

medical disorders; neurophysiology; patient treatment; transcranial magnetic stimulation; Parkinson´s disease; advanced TMS therapy analysis; coil configuration; deep brain TMS coil design; deep brain transcranial magnetic stimulation; electric field; heterogeneous MRI derived head model; human head; mouse brain; neurological disorders; patient treatment; physical magnetic field profiles; Brain modeling; Coils; Computers; Educational institutions; Electric fields; Magnetic stimulation; Mice;

fLanguage

English

Publisher

ieee

Conference_Titel

Neural Engineering (NER), 2013 6th International IEEE/EMBS Conference on

Conference_Location

San Diego, CA

ISSN

1948-3546

Type

conf

DOI

10.1109/NER.2013.6695887

Filename

6695887