Title :
Estimation of internal variables from Hodgkin-Huxley neuron voltage
Author :
Sinha, Aloka ; Schiff, S.J. ; Huebel, Nico
Author_Institution :
Center of Neural Eng. & Mech. Eng. Dept., Pennsylvania State Univ., University Park, PA, USA
Abstract :
This paper presents a novel approach to estimate internal variables such as gating variables, potassium, sodium and chloride concentrations from the knowledge of voltage of a neuron. This approach is based on the Hodgkin-Huxley neuron dynamics and basic ideas behind a Luenberger observer, and utilizes the full nonlinear dynamics. Results from numerical simulations are presented.
Keywords :
bioelectric phenomena; biomembrane transport; chlorine; nonlinear dynamical systems; numerical analysis; potassium; sodium; Cl; Hodgkin-Huxley neuron nonlinear dynamics; Hodgkin-Huxley neuron voltage; K; Na; chloride concentrations; gating variable estimation; internal variable estimation; numerical simulations; potassium concentrations; sodium concentrations; Equations; Extracellular; Mathematical model; Neurons; Observers; Voltage measurement;
Conference_Titel :
Neural Engineering (NER), 2013 6th International IEEE/EMBS Conference on
Conference_Location :
San Diego, CA
DOI :
10.1109/NER.2013.6695905
