Integrated IVUS-OCT Imaging for Atherosclerotic Plaque Characterization

Author

Xiang Li ; JiaWen Li ; Jing, J. ; Teng Ma ; Shanshan Liang ; Jun Zhang ; Mohar, D. ; Raney, A. ; Mahon, S. ; Brenner, Markus ; Patel, Pragati ; Shung, K. Kirk ; Qifa Zhou ; Zhongping Chen

Author_Institution

Dept. of Biomed. Eng., Univ. of Southern California, Los Angeles, CA, USA

Volume

20

Issue

2

fYear

2014

fDate

March-April 2014

Firstpage

196

Lastpage

203

Abstract

For the diagnosis of atherosclerosis, biomedical imaging techniques such as intravascular ultrasound (IVUS) and optical coherence tomography (OCT) have been developed. The combined use of IVUS and OCT is hypothesized to remarkably increase diagnostic accuracy of vulnerable plaques. We have developed an integrated IVUS-OCT imaging apparatus, which includes the integrated catheter, motor drive unit, and imaging system. The dual-function imaging catheter has the same diameter of current clinical standard. The imaging system is capable for simultaneous IVUS and OCT imaging in real time. Ex vivo and in vivo experiments on rabbits with atherosclerosis were conducted to demonstrate the feasibility and superiority of the integrated intravascular imaging modality.

Keywords

biomedical optical imaging; biomedical ultrasonics; catheters; diseases; optical tomography; real-time systems; atherosclerosis diagnosis; atherosclerotic plaque characterization; biomedical imaging technique; clinical standard; diagnostic accuracy; dual-function imaging catheter; imaging system; integrated IVUS-OCT imaging apparatus; integrated catheter; integrated intravascular imaging modality; intravascular ultrasound; motor drive unit; optical coherence tomography; real time imaging; vulnerable plaque; Atherosclerosis; Biomedical imaging; Catheters; Probes; Rabbits; Transducers; IVUS; OCT; intravascular; multimodal;

fLanguage

English

Journal_Title

Selected Topics in Quantum Electronics, IEEE Journal of

Publisher

ieee

ISSN

1077-260X

Type

jour

DOI

10.1109/JSTQE.2013.2274724

Filename

6573330