DocumentCode :
667242
Title :
Studying the correlation between the extracellular environment and the diffusion processes in tumor growth
Author :
Ampatzoglou, Pantelis ; Hadjinicolaou, Maria
Author_Institution :
Sch. of Sci. & Technol., Hellenic Open Univ., Patras, Greece
fYear :
2013
fDate :
10-13 Nov. 2013
Firstpage :
1
Lastpage :
4
Abstract :
The tumor behavior is understood as a complex dynamical system encountering many different scales. Following the principles of Jiang et.al, we also employ a multiscale model, where the environment of a tumor, at the extracellular level is described by reaction diffusion, while at the cellular level an agent based model is applied. We further extend this model by employing a health function, which describes at every time step the health state of any tumor cell. This health function takes into account the biological and biochemical micro environment. A stochastic function is applied to model the mitosis process of proliferating tumor cells.
Keywords :
biochemistry; biodiffusion; cancer; cellular biophysics; chemical reactions; stochastic processes; tumours; agent based model; biochemical microenvironment; cellular level; complex dynamical system; diffusion processes; extracellular environment; extracellular level; health function; health state; mitosis process; multiscale model; reaction diffusion; stochastic function; tumor cell proliferation; tumor growth; Biological system modeling; Cancer; Computational modeling; Extracellular; Mathematical model; Numerical models; Tumors;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Bioinformatics and Bioengineering (BIBE), 2013 IEEE 13th International Conference on
Conference_Location :
Chania
Type :
conf
DOI :
10.1109/BIBE.2013.6701580
Filename :
6701580
Link To Document :
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