Candidate biomarkers for response to tamoxifen in breast cancer metastatic patients

Author

Cava, C. ; Bertoli, G. ; Zoppis, I. ; Mauri, G. ; Gilardi, M.C. ; Castiglioni, I.

Author_Institution

Inst. of Mol. Bioimaging & Physiol., Milan, Italy

fYear

2013

fDate

10-13 Nov. 2013

Firstpage

1

Lastpage

4

Abstract

Tamoxifen is currently used for the treatment of breast cancer. Response to tamoxifen in metastatic conditions is a primary issue in cancer development. We used a cohort of breast cancer patients, treated or not with tamoxifen, and combined these data with the gene signature of metastatic samples in order to investigate the genetic mechanism of metastasis development, in search of a possible therapeutic effect of tamoxifen in metastatic conditions,. The analysis revealed a group of 21 genes common both to the set of up regulated genes in metastatic BC patients and to the set of down regulated genes in tamoxifen treated patients. These genes could be used as biomarkers for tamoxifen-sensitivity in order to optimize BC treatment.

Keywords

cancer; genetics; organic compounds; patient treatment; biomarkers; breast cancer metastatic patients; breast cancer treatment; gene signature; genetic mechanism; tamoxifen-sensitivity; therapeutic effect; Bioinformatics; Breast cancer; Genomics; Metastasis; Niobium; Support vector machines; Tumors;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Bioengineering (BIBE), 2013 IEEE 13th International Conference on

Conference_Location

Chania

Type

conf

DOI

10.1109/BIBE.2013.6701636

Filename

6701636