Title :
Experimental investigation of thermal conductivity of medical nanofluids based on functionalised single-wall carbon nanotube and conjugated cisplatin
Author :
Kazemi-Beydokhti, Amin ; Zeinali Heris, S. ; Jaafari, M.R.
Author_Institution :
Chem. Eng. Dept., Ferdowsi Univ. of Mashhad, Mashhad, Iran
Abstract :
Thermal engineering parameters such as thermal conductivity (TC) can play an important role in developing medical nanofluids with improved stability and better drug release. In this reported work, an engineering perspective is strategised for the development of medical nanofluids containing functionalised single-wall carbon nanotubes and conjugated cisplatin. These nanofluids were developed by two biocompatible phospholipids. For the first time, the change in TC values of this medical nanofluid was investigated. The change in the drug release was examined before and after dialysis with change in pH and temperature, in vitro. It was found that an increase in temperature leads to higher TC and a decrease in pH provides better thermophysical conditions for the drug release. These findings strongly suggest that TC could be an important parameter in the development of medical nanofluids for cancer treatment.
Keywords :
biothermics; cancer; drug delivery systems; drugs; intelligent materials; materials preparation; nanocomposites; nanofabrication; nanofluidics; nanomedicine; pH; single-wall carbon nanotubes; thermal conductivity; C; biocompatible phospholipid; cancer treatment; cisplatin conjugation; dialysis; drug release; in vitro medium; medical nanofluid TC value change; medical nanofluid development; medical nanofluid stability; pH change; single-wall carbon nanotube functionalisation; temperature change; thermal conductivity; thermal engineering parameter; thermophysical condition;
Journal_Title :
Micro & Nano Letters, IET
DOI :
10.1049/mnl.2014.0593