DocumentCode :
67056
Title :
A 0.18 
Biosensor Front-End Based on 
Noise, Distortion Cancelation and Chopp
Author :
Balasubramanian, Vineeth ; Ruedi, P.-F. ; Temiz, Yuksel ; Ferretti, Anna ; Guiducci, C. ; Enz, C.C.
Author_Institution :
Swiss Center for Electron. & Microtechnol., Neuchatel, Switzerland
Volume :
7
Issue :
5
fYear :
2013
fDate :
Oct. 2013
Firstpage :
660
Lastpage :
673
Abstract :
This paper presents a novel sensor front-end circuit that addresses the issues of 1/f noise and distortion in a unique way by using canceling techniques. The proposed front-end is a fully differential transimpedance amplifier (TIA) targeted for current mode electrochemical biosensing applications. In this paper, we discuss the architecture of this canceling based front-end and the optimization methods followed for achieving low noise, low distortion performance at minimum current consumption are presented. To validate the employed canceling based front-end, it has been realized in a 0.18 μm CMOS process and the characterization results are presented. The front-end has also been tested as part of a complete wireless sensing system and the cyclic voltammetry (CV) test results from electrochemical sensors are provided. Overall current consumption in the front-end is 50 μA while operating on a 1.8 V supply.
Keywords :
1/f noise; biosensors; distortion; electrochemical sensors; low noise amplifiers; operational amplifiers; optimisation; voltammetry (chemical analysis); 1/f noise; CMOS process; biosensor front-end circuit; canceling based front-end; chopper stabilization techniques; complete wireless sensing system; current 50 muA; cyclic voltammetry test; distortion cancelation techniques; electrochemical biosensing applications; full differential transimpedance amplifier; low distortion performance; low noise; minimum current consumption; optimization methods; size 0.18 mum; voltage 1.8 V; Biosensors; Choppers (circuits); Harmonic distortion; Logic gates; Noise; Silicon; Thermal noise; $1/{rm f}$ noise; chopping; current mode electrochemical biosensor; distortion canceling; low noise; low power; noise canceling; strong inversion; transimpedance front-end (read-out); weak inversion; Amplifiers, Electronic; Biosensing Techniques; Equipment Design; Noise;
fLanguage :
English
Journal_Title :
Biomedical Circuits and Systems, IEEE Transactions on
Publisher :
ieee
ISSN :
1932-4545
Type :
jour
DOI :
10.1109/TBCAS.2012.2234121
Filename :
6469184
Link To Document :
