Synthesis and characterization of magnetic nanoparticles based on N-palmitoyl-chitosan with potential applications in cancer theranostics

Author

Balan, Viorel ; Butnaru, Maria ; Verestiuc, Liliana

Author_Institution

Dept. of Biomed. Sci., Grigore T. Popa Univ. of Med. & Pharmacy, Iasi, Romania

fYear

2013

fDate

21-23 Nov. 2013

Firstpage

1

Lastpage

4

Abstract

A novel magnetic carrier has been prepared by ionic gelation of N-palmitoyl chitosan with sodium tripolyphosphate, in the presence of magnetite. N-palmitoyl chitosan structure has been confirmed by proton nuclear magnetic resonance (¹H-NMR) and Fourier transform infrared (FT-IR) spectroscopy. Dynamic light scattering measurements showed that magnetic nanoparticles have a hydrodynamic mean diameter of about 150 nm and positive zeta potential. The particles are characterized by high magnetic saturation, superparamagnetic behaviour and exhibit the ability to incorporate a chemoterapeutic agent (Doxorubicin), properties that can be further exploited in cancer theranostics.

Keywords

Fourier transform spectra; biomedical materials; cancer; electrokinetic effects; infrared spectra; light scattering; magnetic particles; nanofabrication; nanomagnetics; nanomedicine; nanoparticles; organic compounds; proton magnetic resonance; superparamagnetism; ¹H-NMR; FT-IR spectroscopy; Fourier transform infrared spectroscopy; N-palmitoyl chitosan structure; cancer theranostics; chemoterapeutic agent; doxorubicin; dynamic light scattering; high magnetic saturation; hydrodynamic mean diameter; ionic gelation; magnetic carrier; magnetic nanoparticles; proton nuclear magnetic resonance; sodium tripolyphosphate; superparamagnetic behaviour; zeta potential; Biomedical imaging; Hydrodynamics; Immune system; Magnetic resonance imaging; N-palmitoyl chitosan; cancer theranostics; ionic gelation; magnetic nanoparticles;

fLanguage

English

Publisher

ieee

Conference_Titel

E-Health and Bioengineering Conference (EHB), 2013

Conference_Location

Iasi

Print_ISBN

978-1-4799-2372-4

Type

conf

DOI

10.1109/EHB.2013.6707322

Filename

6707322