Title :
Novel semi-interpenetrating polymer networks based on functionalized chitosan and poly(acrylic acid) with potential applications in soft tissue engineering
Author :
Rusu, Alina Gabriela ; Vulpe, Raluca ; Popa, Marcel Ionel ; Butnaru, Maria ; Verestiuc, Liliana
Author_Institution :
Dept. of Natural & Synthetic Polymers, Gh. Asachi Tech. Univ., Iasi, Romania
Abstract :
Hydrogels with semi-interpenetrating (semi-IPN) structure were synthesized by radical copolymerization of maleoyl-chitosan (N-MA-Cs) and acrylic acid (AA) in the presence of ammonium persulfate (APS) and N,N,N´,N´-tetramethylethylenediamine (TEMED) as initiating system. Network structure and morphology were confirmed by Fourier Transform Infrared Spectroscopy coupled with Attenuated Total Reflection technique (ATR-FTIR) and scanning electron microscopy (SEM). Water uptake in scaffolds is influenced by both composition and the porosity of the matrices. The prepared scaffolds are degradable by lysozyme and the degradation rate can be modulated by the content of acrylic acid. The materials cytocompatibility and physical-chemical characteristics indicate that these scaffolds exhibit the prerequisite behaviour for use in soft tissue engineering.
Keywords :
Fourier transform spectra; biomedical materials; cellular biophysics; hydrogels; infrared spectra; materials preparation; polymer blends; polymer structure; polymerisation; porous materials; scanning electron microscopy; tissue engineering; ATR-FTIR spectroscopy; Fourier transform infrared spectroscopy; N,N,N´,N´-tetramethylethylenediamine; N-MA-Cs; SEM; TEMED initiating system; acrylic acid content; ammonium persulfate; attenuated total reflection technique; cytocompatibility; degradation rate; functionalized chitosan; hydrogel semiIPN structure; lysozyme degradable scaffolds; maleoyl-chitosan; matrix composition; matrix porosity; network morphology; network structure; physical-chemical characteristics; poly(acrylic acid); radical copolymerization; scaffold water uptake; scanning electron microscopy; semiinterpenetrating polymer networks; soft tissue engineering; Polymers; Scanning electron microscopy; Skin; cytocompatible materials; hydrogels; radical copolymerization; semi-interpenetrating networks; soft tissue engineering;
Conference_Titel :
E-Health and Bioengineering Conference (EHB), 2013
Conference_Location :
Iasi
Print_ISBN :
978-1-4799-2372-4
DOI :
10.1109/EHB.2013.6707339
