Optical and electron microscopy in detecting degenerative changes at patients with primary and ischemic myocardic diseases

Author

Branishte, Tudor ; Braniste, Andrei

Author_Institution

“N. Testemitanu” Med. & Pharm. Univ., Chisinau, Moldova

fYear

2013

fDate

21-23 Nov. 2013

Firstpage

1

Lastpage

4

Abstract

The aim of this study was to relate particular aspects of morphological and immunohistochemical alterations of apoptotic degeneration in patients with MC, CMD, MIC, IC. The morphologic and immunohistochemical analysis of subendocardiac bioptates was carried out to 201 patients with CM, DCM, ICM and IC with FC I-IV NYHA circulatory insufficiency. Phenomena of apoptopic degeneration of the cardiomyocytes were detected in all nosologic entities included in the study, except for the subacute myocarditis and the ones intermediary to the subacute and chronic forms. The percentage apoptopic index was: DCM - 2,19±0,82; CM - 2,21±0,81; ICM - 2,25±0,86 and reflects the seriousness of morphofunctional changes of the heart with the signaled pathologies.

Keywords

biochemistry; biomedical optical imaging; cardiology; diseases; electron microscopy; medical disorders; optical microscopy; CM insufficiency; DCM insufficiency; FCI-IV NYHA circulatory insufficiency; IC insufficiency; ICM insufficiency; apoptopic degeneration phenomena; apoptotic degeneration; cardiomyocytes; chronic forms; electron microscopy; heart; immunohistochemical analysis; ischemic myocardic diseases; morphofunctional changes; morphologic analysis; morphological alterations; nosologic entities; optical microscopy; percentage apoptopic index; primary myocardic diseases; signaled pathology; subacute myocarditis; subendocardiac bioptates; Diseases; Electron microscopy; Heart; Immune system; Myocardium; Proteins; apoptosis; cardiomyopathy; microscopy; myocarditis;

fLanguage

English

Publisher

ieee

Conference_Titel

E-Health and Bioengineering Conference (EHB), 2013

Conference_Location

Iasi

Print_ISBN

978-1-4799-2372-4

Type

conf

DOI

10.1109/EHB.2013.6707363

Filename

6707363