DocumentCode :
674055
Title :
Heterogeneous electrical remodeling of the failing heart modulates the arrhythmogenic substrate
Author :
Gomez, J.F. ; Cardona, K. ; Romero, Lucila ; Saiz, J. ; Trenor, B.
Author_Institution :
Univ. Politec. de Valencia, València, Spain
fYear :
2013
fDate :
22-25 Sept. 2013
Firstpage :
49
Lastpage :
52
Abstract :
Failing hearts undergo electrical and structural remodeling, setting the stage for malignant arrhythmias. Increased dispersion of repolarization has been suggested to underlie increased arrhythmogenesis in human heart failure (HF). Recent experimental studies have shown that transmural dispersion of repolarization (TDR) decreases in failing hearts, while others have observed an increase in similar conditions. In this simulation work, we try to elucidate different mechanism of modulation of the repolarization gradient in failing human hearts and its implication for arrhythmogenesis. The human ventricular action potential (AP) models formulated by O´Hara et al. (ORd) and Grandi et al. (GPB) were modified to simulate the electrical remodeling observed in human heart failure. Several biomarkers (APD90, triangulation (APD90-APD50), Ca+2 decay, Ca+2 dynamics, systolic Na+ and AP-Ca+2 Delay) were measured and calculated from individual ventricular cells simulations under different conditions of heterogeneous remodeling, modulating the changes in INCX and ISERCA in endocardial, midmyocardial and epicardial cells. The results of this study uncover the importance of the existence of M cells and how heterogeneous remodeling can modulate the gradient of AP repolarization and Ca2+ handling in failing hearts.
Keywords :
bioelectric potentials; biomembrane transport; calcium; medical disorders; physiological models; positive ions; sodium; Ca+2; M cell existence; Na+; TDR; arrhythmogenic substrate; biomarkers; calcium ion decay; calcium ion dynamics; endocardial cells; epicardial cells; heterogeneous electrical remodeling; human heart failure; human ventricular action potential models; malignant arrhythmias; midmyocardial cells; systolic sodium ion; transmural dispersion of repolarization; triangulation APD90-APD50β; ventricular cell simulations; Abstracts; Biological system modeling; Biomarkers; Computational modeling; Electric potential; Hafnium; Heart;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Computing in Cardiology Conference (CinC), 2013
Conference_Location :
Zaragoza
ISSN :
2325-8861
Print_ISBN :
978-1-4799-0884-4
Type :
conf
Filename :
6712408
Link To Document :
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