Title :
Validation of a computational model of cardiac defibrillation
Author :
Bragard, Jean ; Elorza, Jorge ; Cherry, Elizabeth M. ; Fenton, Flavio H.
Author_Institution :
Univ. de Navarra, Pamplona, Spain
Abstract :
We develop and validate a three-dimensional model of ventricular fibrillation for use in studying defibrillation. Specifically, we use a rabbit ventricular geometry as a realistic model system for evaluating the efficacy of defibrillatory shocks. Data obtained from the simulations are analyzed in terms of a dose-response curve. In agreement with clinically relevant values, we find that an electric field strength of about 6.6 V/cm indicates a 50% probability of successful defibrillation for a 12-ms monophasic shock in our model. Our validated model will be useful for optimizing defibrillation protocols and for performing detailed studies of defibrillation mechanisms.
Keywords :
bioelectric potentials; diseases; dosimetry; electrocardiography; probability; cardiac defibrillation; computational model validation; defibrillatory shocks; dose-response curve; electric field strength; electrocardiography; monophasic shock; probability; rabbit ventricular geometry; realistic model system; three-dimensional model; time 12 ms; ventricular fibrillation; Abstracts; Analytical models; Computational modeling; Manuals;
Conference_Titel :
Computing in Cardiology Conference (CinC), 2013
Conference_Location :
Zaragoza
Print_ISBN :
978-1-4799-0884-4