DocumentCode :
686941
Title :
Dual isotope SPECT imaging of I-123 and I-125
Author :
Sanghyeb Lee ; Gregor, J. ; Osborne, Dustin ; Wall, Julie
Author_Institution :
Dept. of Electr. Eng. & Comput. Sci., Univ. of Tennessee, Knoxville, TN, USA
fYear :
2013
fDate :
Oct. 27 2013-Nov. 2 2013
Firstpage :
1
Lastpage :
4
Abstract :
Peripheral amyloidosis is a debilitating and often fatal disease. SPECT imaging of amyloid in mice has been established using 125I-SAP. Current efforts are aimed at using 125I-labeled synthetic peptides such as p5, which are easier to translate into the clinic in the US since SAP is of human origin. It needs to be shown that the new peptide biomarkers correlate well with the gold standard, SAP. As both materials can be radioiodinated using facile chemistry, the challenge then becomes to develop a protocol that supports dual isotope SPECT imaging of 123I-labeled SAP and the 125I-labeled peptide. We address this challenge by first quantifying the amount of cross-talk between the two radio nuclides. We subsequently suggest a correction method.
Keywords :
biochemistry; diseases; molecular biophysics; proteins; radioisotopes; single photon emission computed tomography; 123I-labeled SAP; 125I-SAP; 125I-labeled synthetic peptides; SAP; dual isotope SPECT imaging; facile chemistry; fatal disease; peptide biomarkers; peripheral amyloidosis; radioiodinated materials; radionuclides; Attenuation; Collimators; Detectors; Logic gates; Photonics; Single photon emission computed tomography;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2013 IEEE
Conference_Location :
Seoul
Print_ISBN :
978-1-4799-0533-1
Type :
conf
DOI :
10.1109/NSSMIC.2013.6829377
Filename :
6829377
Link To Document :
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