DocumentCode :
686956
Title :
A 5D anthropomorphic numerical phantom for respiratory-gated parametric imaging simulation studies in dynamic emission tomography
Author :
Kotasidis, Fotis A. ; Tsoumpas, Charalampos ; Polycarpou, Irene ; Zaidi, Habib
Author_Institution :
Div. of Nucl. Med. & Mol. Imaging, Geneva Univ. Hosp., Geneva, Switzerland
fYear :
2013
fDate :
Oct. 27 2013-Nov. 2 2013
Firstpage :
1
Lastpage :
3
Abstract :
Dynamic image acquisition protocols are increasingly used in emission tomography, for drug development and clinical research. As such, there is a need for computational phantoms accurately describing both the spatial as well as temporal distribution of the radiotracer, taking into account periodic and non-periodic physiological processes during the course of the acquisition, such as tracer kinetics and respiratory motion. To this end, we developed a new 5D anthropomorphic digital phantom for accurate parametric imaging simulation studies in emission tomography. The proposed phantom is comprised of 3 spatial and 2 temporal dimensions and is based on high spatial and temporal information derived from 4D MR data. The envisaged applications of this digital phantom include development and evaluation of motion correction and image reconstruction algorithms in PET and SPECT, development of protocols and methods for tracer and drug development and new kinetic parameter estimation algorithms amongst others. Example applications are shown in parametric [18F]FDG and [15O]H2O PET imaging.
Keywords :
anthropometry; biomedical MRI; image motion analysis; image reconstruction; medical image processing; phantoms; positron emission tomography; single photon emission computed tomography; 4D MR data; 5D anthropomorphic numerical phantom; SPECT; [15O]H2O PET imaging; computational phantoms; digital phantom; drug development; dynamic emission tomography; dynamic image acquisition protocol; image reconstruction algorithm; kinetic parameter estimation algorithm; motion correction algorithm; nonperiodic physiological process; parametric [18F]FDG PET imaging; respiratory-gated parametric imaging simulation; spatial dimension; spatial radiotracer distribution; temporal dimension; temporal radiotracer distribution; Dynamics; Imaging phantoms; Kinetic theory; Logic gates; Phantoms; Positron emission tomography; Computational phantom; MRI; PET; parametric imaging; respiratory motion;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2013 IEEE
Conference_Location :
Seoul
Print_ISBN :
978-1-4799-0533-1
Type :
conf
DOI :
10.1109/NSSMIC.2013.6829392
Filename :
6829392
Link To Document :
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