Title :
Label-free kinetic screening of proteins and virus binding in A 51,200 small-molecule library with a high-throughput ellipsometric scanning microscope
Author :
Malovichko, G. ; Landry, James P. ; Proudian, Andrew P. ; Xiangdong Zhu
Author_Institution :
Dept. of Phys.., Univ. of California at Davis, Davis, CA, USA
Abstract :
Using a label-free high-throughput optical scanning microscope we detected endpoints and binding kinetics of RNPC1a, Pyl(1&2) proteins and influenza virus A/PR/8/34 with a library of 51,200 small-molecule compounds from the NCI Developmental Therapeutics Program.
Keywords :
ellipsometry; microorganisms; molecular biophysics; optical microscopy; proteins; RNPC1a binding kinetics; high-throughput ellipsometric scanning microscope; influenza virus binding kinetics; label-free kinetic screening; protein binding kinetics; small-molecule compounds; Biomedical optical imaging; Compounds; Kinetic theory; Libraries; Probes; Proteins; Real-time systems;
Conference_Titel :
Lasers and Electro-Optics (CLEO), 2013 Conference on
Conference_Location :
San Jose, CA
