Human Arteries Modeling and Central Aortic Pressure Estimation

In this paper, we present a novel viscous fluid mechanics based Arteries Modeling and Central Aortic Pressure (CAP) Estimation method (M-CAP). According to the blood fluid dynamics equations, the behavior of artery vessels system can be modeled by a network of electrical circuit consisting of resistances, inductances and capacitances. The transfer function between radial artery and central aortic is then derived based on the electrical network. Via measuring the pulse wave of the proximal and distal ends of the radial artery, the least square method is proposed to estimate the patient-specific electrical network/the transfer function parameters. Thus the central aortic pressure and pulse wave can then be obtained. An invasive validation study with 50 subjects comparing M-CAP with direct aortic root pressure measurements during cardiac catheterization were carried out at the Beijing Hospital. The experimental results have shown better performance of M-CAP method can be achieved comparing to ground-truth.